Journal: Translational Cancer Research
Article Title: SNORD93 suppresses colorectal cancer progression by inducing G0/G1 arrest and apoptosis
doi: 10.21037/tcr-2025-1236
Figure Lengend Snippet: Reduced SNORD93 expression in CRC. (A) Expression levels of the SNORD93 mRNA in 13 CRC tissues and paired adjacent tissues were determined via qRT-PCR analysis (P=0.03), normalized to 18S rRNA. (B) Expression levels of the SNORD93 mRNA in CRC cell lines (SW480, HT-29, and HCT-15) relative to normal HIEC controls, quantified by qRT-PCR analysis (HIEC: SW480, P<0.001; HIEC: HT-29, P<0.001; HIEC: HCT-15, P=0.002). (C) Prognostic relevance of SNORD93 abundance in colorectal cancer survival outcomes. Green color indicates patients with CRC and low SNORD93 expression, while red color indicates patients with CRC and high SNORD93 expression (P=0.001). Data are presented as mean ± SD (n=3). *, P<0.05; **, P<0.01; ***, P<0.001. CRC, colorectal cancer; HIEC, human intestinal epithelial crypt cell; mRNA, messenger RNA; NT, normal tissue samples; qRT-PCR, quantitative real-time polymerase chain reaction; rRNA, ribosomal RNA; SD, standard deviation; T, tissue samples.
Article Snippet: The human CRC cell lines HT-29 (HTB-38), SW480 (CCL-228), and HCT-15 (CCL-225), and the normal human intestinal epithelial crypt cell (HIEC) line (CRL-3266) were sourced from the American Type Culture Collection (ATCC; Manassas, VI, USA).
Techniques: Expressing, Quantitative RT-PCR, Real-time Polymerase Chain Reaction, Standard Deviation